Intermediates 

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Manufacturers of basic building blocks, standard active ingredients and intermediates.
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A-Z Intermediates Provider Directory
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A
Aarti Group
Manufacturer and exporter of bulk drugs, dye intermediates, plasticizers, industrial chemicals, specialty chemicals and formulations.
www.aartigroup.com
Advanced Asymmetrics, Inc.
Manufacturer and supplier of compounds for chiral synthesis in research and development quantities, products include chiral precursors, auxiliaries, and catalysts.
www.advancedasymmetrics.com
Aerojet Chemical
Developer and manufacturer of fine chemical intermediates and bulk APIs; specializing in propellants and azides. Located in Rancho Cordova, California.
www.aerojetfinechemicals.com
Automation for Industry, Inc.
Manufacturer and designer of motor and machine controls, specializing in stepper controls, brushless DC controls and AC and DC speed controls. The company is also a distributor of motors that can be driven with AFI controls. Products are sold ...
www.afimotion.com
AliaPharm
Manufacturer of fine chemicals and pharmaceuticals and intermediates. Products include acids and salts, halogenated aromatics and amines.
www.aliapharm.de
Alkaloid
Manufacturer and developer of pharmaceuticals, botanicals, paints & lacquers, and fine organic reagents.
www.alkaloid.com.mk
Allchem International
Provider of high-purity intermediates, biochemicals and petrochemicals for cosmetics, pharmaceuticals and coatings.
www.allchem.co.uk
Amines & Plasticizers Ltd.
An Indian based manufacturer of plasticizers which includes phthalates, sebacates, trimellitates, acetates, maleates, methyl diethanolimine (MDEA), and ethylene oxide derivatives.
www.amines.com
Amsa
International developer and manufacturer of DTEA and DBNPA based chemicals and other specialized fine reagents. Offices located in Midland, Michigan USA.
www.amsainc.com
Asymchem
North Carolina based custom synthesis producer of advanced fine organic chemical and pharmaceutical intermediates; products include benzotrifluorides, fluoroaromatic compounds, bromoaromatic, indole and oxindole derivatives, pyridine derivati...
www.asymchem.com
Atul
International manufacturer and distributor of agrochemicals, caustic soda and potash, chlorine, sulphuric acid, dyes and pigments intermediates, drug intermediates, epoxy hardeners and resins, formaldehyde and hexamine and manganese compounds.
www.atul.co.in
Avecia
International manufacturer and developer of specialty chemicals including biocides, biological actives and drug intermediates, agrochemicals and biotechnology, performance and intermediate chemicals, pigments and additives and water-based resins...
www.avecia.com
B
Bayer US
Research-based company with major businesses in health care and life sciences, chemicals and imaging technologies.
www.bayerus.com
Bruno Bock Chemische Fabrik GmbH & Co. KG
Manufacturing thioglycol acidity, thiomilk acidity, mercaptocarbon acidity and their follow-up products.
www.bock-thiochemicals.com
Boulder Scientific Company
International producer and distributor of organometallics, pharmaceuticals, polymers, Grignard reagents, metallovenes, boron compounds, and other specialty chemicals. Located in Colorado USA.
www.bouldersci.com
C
Camida
Manufacturer of specialty and fine chemicals, organic intermediates and food ingredients.
www.camida.com
Carbomer
Supplier of engineer synthetic biopolymers, carbohydrates, pharmaceuticals, and other specialized polymers and biochemicals.
www.carbomer.com
Cayman Chemicals
Michigan based supplier of fine reagents, specializing in antibodies, neurochemistry, apoptosis, nitric oxide, cyclooxygenase, nuclear eceptors, enzyme immunoassay, fatty acids, leukotrienes, and biochemicals. Locate in Ann Arbor, Michigan ...
www.caymanchem.com
Changyu Chemical Plant
Producer of chemical intermediates such as pesticides, pharmaceuticals, dyestuff, and other specialized chemical reagents. Located in Zhangjiagang City, Jiangsu, China.
www.changyuhg.com
Chemagis
Involved in the production of dihydrochloride, clarithromycin, clobazam, dobutamine hydrochloride, fluticasone propionate, midazolam base, midazolam meleate, moxonidine, pentoxifylline, and tranadol hydrochloride. Located in Tel Aviv, Israel.
www.chemagis.co.il
Chemi
Custom fine chemical manufacturer of chiral intermediates, peptides and peptide intermediates, phospholipids and generic active ingredients for the pharmaceutical industry.
www.chemi.com
Chemicals Incorporated
Manufacturer of specialty chemicals, pharmaceutical intermediates, flavors and fragrances, basic adhesives and metal carboxylate dryers. Products include engineering resins, lube additives, polymer additives and naphthenates.
www.chemicalsinc.com
Chemwerth
Supplier of active pharmaceutical intermediates specializing in antibiotic and oncology products mainly from manufacturers in China.
www.chemwerth.com
Sozhou Branch of Nantong Sunda Amino Acid
Manufacturer and exporter of amino acids, fluorine salts and bromine salts, including glycines and derivatives as well as drug intermediates.
www.china-sunda.com
Yancheng No.4 Chemical Factory
Supplier of bromobenzene, ethyl bromide, n-propyl bromide, 2-bromo propane, n-butyl bromide.
www.chinabromide.com
Shanxi Kangyuan Chemical
Specialty chemical manufacturer of aromatic derivatives, main products include 3-nitro-O-xylene; 1,3,5-triphenol; 4-nitro-O-xylene; 2,3-dimethyl phenol; 2,5-dimethyl-nitrobenzene; 2,6-dimethyl-nitrobenzene; 2,4-dimethyl-nitrobenzene; 2,3-xylidin...
www.chinachemnet.com
Yangzhou Gaokang Group
Manufacturer dealing in dyestuff products, intermediate products and medicine products in China.
www.chinafinechem-indus.com
Hangzhou Chiral Fine Chemical
Producer of pharmaceutical intermediates and chiral conmpounds.
www.chiralchem.com
Hangzhou Changlong Chemical
Manufacturer of pharmaceutical intermediates, cationic surfactants, dye additives and inorganic chemicals.
www.clhg.com
Czech Moravian & Slovak Chemicals
Manufacturers of specialty chemicals including carbohydrates, disaccharides, oligosaccharides, protected sugars, pyridine derivatives, isocyanates, organic intermediates and custom synthesis. Oxford based with production facilities in Central Eu...
www.cms-chemicals.com
Shanxi Ruicheng Chemical
Developer and manufacturer of drug intermediates, pesticides, dyes, plastic additives and other specialty and fine chemicals.
www.cnruihua.com
Colour-Chem
Indian manufacturer of pigments and additives, life science and electronic chemicals, textile chemicals, cellulose ethers and functional chemicals including detergents.
www.colour-chem.com
Combi-Blocks.com
Online specialty chemical supplier, providing aryboronic acids, vinylboronic acids, imidazoles, indoles, analines and nitrobenzene, resins, scavengers, linkers, glassware and custom synthesis services.
www.combi-blocks.com
Crystal Chem
Supplier of biochemicals, immunochemicals, molecular biology reagents and antibodies.
www.crystalchem.com
D
Delmar
Manufacturer and marketer of active pharmaceutical ingredients, pharmaceutical intermediates and other organic fine chemicals.
www.delmarchem.com
Dixie Chemical
Manufacturer of high-purity specialty and complex chemicals and pharmaceutical intermediates for domestic and export areas.
www.dixiechemical.com
D.K. Chemicals
Manufacturer of intermediate for bulk drugs, pharmaceuticals, dyes and pesticides, catalyst for esterification, plasticizers, resins, pigments and detergents.
www.dkchemicals.com
D&OChemicals
International supplier and developer of pharmaceutical intermediates and custom manufacturing.
www.dochem.com
DSM
International group of chemical manufacturers active in drug intermediates, basic food ingredients, engineering plastics, resins, synthetic rubbers and other perfomance materials, basic polymers, enzyme technologies, caprocalctam, melamine and E...
www.dsmna.com
E
East Coast Biologics
Bulk supplier of raw chemicals to the immunodiagnostic manufacturing industry as well as the research community worldwide.
www.eastcoastbio.com
EMS-Dottikon
ISO 9001 certified producer of organic intermediates and active ingredients from pilot to multi-thousand ton range for the pharmaceutical and chemical industry, also provides custom synthesis. Locations in Switzerland and USA.
www.ems-dottikon.ch
Euro Asian Industrial
Manufacturer of dyes, intermediates, bulk drugs, and veterinary products.
www.euroasian.net
Exsymol
Produces pharmaceutical and cosmetic active ingredients. The production deals with synthetic actives, natural-derived actives, vehicles, and complexes of targeted actives.
www.exsymol.com
F
Shenzhen Fangye Industries
Producer, developer and exporter of fine chemicals, pharmaceutical intermediates, cosmetic raw materials and biochemical reagents, pesticide intermediates and dyestuff intermediates.
www.fangye.com
Shanghai Luyuan Fine Chemical Factory
Manufacturer of pharmaceutical health care products, intermediates, food and feed additives, and chemical reagents. Based in China.
www.finechem-china.com
Frontier Scientific, Inc.
Producer of porphyrins, boronic acids and bile pigments. Provider of custom chemical solution formulation services. Products and services are provided to hospital and university research facilities.
www.frontiersci.com
G
Ganes Chemical
Global supplier of generic active pharmaceuticals ingredients (APIs), custom manufacturing and comprehensive pharmaceutical services, working in strict confidentiality with our partners.
www.ganes.com
Gayatri Minerals & Chemicals
Manufacturer of fine chemicals and inorganics, including ortho chloro benzaldehyde and benzaldehyde 2-sulphonic acid sodium salt as well as other drug intermediates.
www.gayatrionline.com
GTF Labs
Wholesaler of specialty chemical intermediates products for the manufacture of soaps, including lye, citric acid, epson salts and oils.
www.gtflabs.com
H
Heterene, Inc.
Manufacturer of specialty esters, lanolin specialties, emulsifying waxes, polyoxypropylene and polyoxyethylene esters, polyoxyethylene sorbitan esters, polyoxyethylene specialties, polyoxyethylene fatty amines, alkanolamides, and amido amines.
www.heterene.com
Hickson and Welch
Contract custom manufacturer and producer of fine chemicals including optical brightening agents, pharmaceutical and dyes and pigment intermediates.
www.hicksonandwelch.co.uk
Zhejiang LianHe Chemical Group
Producer of intermediates, P/C & disperse dyes.
www.hlchem.com
Hoechst
International alliance of companies whose interests are focused on life sciences, notably drugs, agriculture, nutrition and animal health.
www.hoechst.com
Houghton Chemical Corporation
Manufacturers and distributors of specialty chemicals, including heat transfer fluids, water treatment reagents, acids, alcohols, aldehydes, ethyl alcohols, amines, chlorinated solvents, esters, glycols, silicones and surfactants.
www.houghton.com
Hovione
Process chemistry developer, manufacturer and custom synthesis of active pharmaceutical ingredients (API) under GMP, ISO9000 certification and FDA compliance from pilot scale to commercial ton quantities.
www.hovione.com
H&S Chemical Co. Inc.
Developer and producer of fine organics and inorganics, specializes in chloramine-T, pyridine, iodides, methyl fluoride, hydriodic acid, and DDCP. Located in Covington, Kentucky USA.
www.hschem.com
J
Chiral Alcohols
Producer of chiral alcohols, oxidoreductase, enzymes and carbohydrates.
www.juelich-enzyme.com
K
Kowa
Group producing pharmaceuticals, information technology equipment, optical technology, textiles and fibers, fine and specialty chemicals including isocyanates, acrylates, methacrylates, acrylamides, amines, HCN derivatives and photo initiators.
www.kowa.com
L
Lab Vision Corp.
Manufacturer of an automated, XYZ robotic, Windows driven fluid handling device. The device has built-in process control software. The device picks up the fluid being tested, places it on a microscope slide, rinses it off and then places anoth...
www.labvision.com
Wuxi Lida Chemical
Producer of dye intermediates, pharmaceutical intermediate, pesticide intermediate and textile auxiliary.
www.lidachem.com
Lurgi Life Science
Manufacturer of pharmaceuticals and intermediates and fine chemicals products, including oleochemicals, vitamins, emulsifiers, hormones, edible oils, fatty acids, starch and derivatives.
www.lurgi-lifescience.com
M
Macrocyclics
Supplier of macrocyclic ligand derivatives mainly for the research community.
www.macrocyclics.com
Mediapolis, Inc.
Provider of interactive web site design and development and security consulting services. Services are provided to multiple industries. This company was capitalized by private investment.
www.mediapolis.com
Montco Research Products
Specialty intermediate chemicals manufacturer, products include ethyl benzyl chloride, 1-chloromethylnaphthalene and 1-naphthaldehyde.
www.montcoresearch.com
N
Neville Chemical Company
Manufacturer of synthetic hydrocarbon resins and coumarone-indene resins. Corporate headquarters and main manufacturing facility located on Neville Island.
www.nevchem.com
O
Hangzhuo Orichem
Manufacturer of specialty dyes and organic intermediates, including benzene, naphthalene and anthraquinone intermediates.
www.orichem.com
Ocean Trading Corporation
Global suppliers of Specialty Chemicals, Bulk Drugs Intermediates, Bulk drugs, Veterinary Products, Intermediates for Agrochemicals and Intermediates for Dyes and Pigments.
www.otcchem.com
P
Affinity Research Products Limited
Manufacturer and developer of high purity functional and intermediate chemicals mainly for the life sciences and research.
www.peptides.com
Pfanstiehl Laboratories
Producer of rare sugars, carbohydrates, and related fine and biological chemicals for use as bulk intermediates and bulk active drug substances by the pharmaceutical, food, cosmetic, dietary supplement and related industries. Headquarters locate...
www.pfanstiehl.com
Pharma Tech International
Provider of custom synthesis services. Also supplies complex organic intermediates, APIs, biochemicals and natural products.
www.pharmatech.org
Plant Organics
India based intermediate chemical manufacturer for the pharmaceutical industry, provides sulphamethaxazole, trimethoprim and Norfloxacin.
www.plantorganics.com
Polyphenols AS
Producer of high purity anthocyanins and other polyphenols.
www.polyphenols.com
Purecha Group of Industries
India based manufacturers of fine chemicals and pharmaceutical intermediates, specializing in bromination compounds.
www.purechagroup.com
R
Ryscor Science, Inc.: Custom Chemical Manufacturer
Specializes in boron chemistry and custom chemical synthesis. Provides boronic acids for combinatorial chemistry and custom chemical manufacturing.
www.ryscor.com
S
Saurav Chemicals
International producer of bromo compounds, pthalimide, phenidone - A, and other fine organic reagents for the pharmaceutical, agrochemical industries.
www.sauravchemicals.com
Merk Schuchardt
Manufacturer and supplier of fine organic intermediates. Also provides custom synthesis services.
www.schuchardt.de
SAMSUNG FINE CHEMICALS
Korea based manufacturer of biotech and fine chemicals, mojor products include epichlorohydrin (ECH), mecellose, l-cartine, dimethylformamide (DMF), tetramethylammonium chloride (TMAC) and malonate.
www.sfc.samsung.co.kr
Signet Laboratories
Manufacturer of prediluted and concentrated antibodies, detection kits, and ancillary reagents designed to meet immunochemical requirements. Located in Dedham, MA, USA.
www.signetlabs.com
Sina Chemical
Producer of formalin and hexamine, based in Iran.
www.sinachem.com
Xishan No. 3 Chemicals and Additives Factory
Manufacturer of specialty dyes and pigments as well as drug intermediates p-aminophenol, paraetamol and a series of disperse dyes.
www.sinodyes.com
Sipsy
Produces Pharmaceutical intermediates and bulk Medicinal Drugs and performs multi-step chemical reactions under cGMP conditions.
www.sipsy.com
Sloss Industries Corporation Chemicals
Diversified manufacturer of specialty chemicals, slag wool fiber and derivative fiber products and coke for both blast furnaces and foundries.
www.sloss.com
SNPE Group
Developer and manufacturer of fine chemicals and multi-stage synthesis custom services serving the pharmaceutical, drug intermediate, agrochemicals and nitrocellulose industries.
www.snpe.com
Sumitomo Seika Chemicals
International chemical manufacturer of fine chemicals, drug intermediates, agrochemicals, photograph chemicals, water-soluble polymers, powder plastics, engineering resins, fine sulfurs and high-purity gases, including hydrogen.
www.sumitomoseika.co.jp
T
Yixing Tianpeng Fine Chemical Industry
Manufacturer of fine chemicals and dyestuffs.
www.tianpengchemicals.com
Tokyo Chemical Industry
International specialty organic chemical manufacturer. Products include analytical reagents, standard materials, pyridines, nitriles, olefins alcohols, drug intermediates and functional reagents.
www.tokyokasei.co.jp
Zhejiang Tongfeng Chemical Factory
Producer of fine chemicals such as intermediates of pharmaceuticals, dyestuffs and photosensitive materials.
www.tongfengchem.com
Twin Lake Chemical
Producers of organic and inorganic chemical intermediates, specializing in organic acid chlorides and phosphorus pentachloride.
www.twinlakechemical.com
U
Ubichem
Manufacturer and exporter of fines and intermediates, biochemicals and enzymes as well as photographic and reprographic agents.
www.ubichem.com
Rhodia North America
Specialty chemical manufacturer of fine organics and intermediates for pharmaceuticals, industrial coating, and silicons and engineered plastics.
www.us.rhodia.com
V
Vani Group
Manufacturer of specialty and fine chemicals, including drug intermediates, photographic reagents and phenyl hydrazin derivatives.
www.vanigroup.com
Vihita Chem Private Limited
Manufacturer and exporter of drug intermediates and specialty chemicals, products include guanidine nitrates and other fine reagents.
www.vihita.com
W
Crompton
International producer and distributor of polymer products and specialty chemicals. Specializes in adhesives and sealants, oil field equipment services, personal care, pharmaceuticals, paints and other specialized reagents.
www.witco.com
Y
Yasho Industries
Specialty chemical manufacturer of cosmetic ingredients, antioxidants, pharmaceuticals, fragrances, flavors, plastic and rubber additives.
www.yashoindustries.com
  • Akzo Nobel N.V.
  • Cie Francaise Des Produits Indust'l-cfpi
  • Edn - Estireno Do Nordeste S.a.
  • Korea Fine Chemical Company Limited
  • Nitto Chemical Industry Co., Ltd.
  • Stepan Company
  • Sterling Chemicals, Inc.
  • Union Carbide Corporation
  • Zhejiang Longsheng Group Co., Ltd.

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Guide to Intermediates

Intermediates function as the starting point to help make most commercial and consumer products

By Deneatra Harmon


Intermediates are defined as chemicals that are combined with solvents to form other products. They provide the base for materials produced in a variety of industries, including textiles, agriculture, cleaning and health care. The most common include chemical intermediates for clothing and other textiles, pharmaceutical intermediates for prescription drugs and dye intermediates used as food additives or as detergents.

There are three common solvents that produce chemical intermediates, dye intermediates and pharmaceutical intermediates. Benzene is an aromatic that mixes with sulfuric acid to form a chemical intermediate, which is then applied to products such as paints, nylon or polyurethanes. Xylene is used as a chemical intermediate for gasoline, polyester and plastics such as beverage bottles. Toluene is an intermediate used to manufacture inks, adhesives, coatings and pharmaceuticals. If you work in a laboratory, a manufacturing plant or a small business that works with such intermediaries, here's what you should consider in order to launch a successful product:

1. Research and seek support services to help get your project off the ground.

2. Determine whether you need chemical intermediates, dye intermediates, drug intermediates or a variety of the three.

3. Obtain the equipment and supplies necessary for safe handling and product enhancement.

Action Steps
The best contacts and resources to help you get it done


Find research and support services through chemical intermediate suppliers

Chemical intermediate manufacturers supply materials and equipment in a broad range of industries, including biotechnology, engineering, pharmaceuticals, personal care and textiles.

I recommend: Mitsui Chemicals America produces bulk pharmaceuticals as well as intermediates for industries ranging from health care to electronics. Clariant produces intermediate chemicals and provides research services to the agricultural, cosmetics, personal care and cleaning industries.

Decide on the types of intermediates necessary to build or mix your product

Determine the need for chemical intermediates, drug intermediates and dye intermediates, depending on the business.

I recommend: Spectrum Chemicals maintains one of the largest inventories of chemical intermediates focusing on the pharmaceutical, nutraceutical and chemical industries. Wego Chemical & Mineral is a chemical intermediate supplier for the agriculture, textile and colorant markets. Dye intermediates are also available. Alfa Chemical distributes chemical intermediates as well as pharmaceutical intermediates to universities, hospitals and research and manufacturing markets.

Get the equipment and accessories to test and handle intermediates

Having the right equipment and supplies ensures proper handling and processing of intermediates.

I recommend: Rubicon manufactures and supplies shell and tube heat exchangers that process chemical intermediates. Fluid Energy Process and Equipment Company designs and builds milling, drying, classifying and particle sizing systems that are compatible with chemical intermediates.

Tips & Tactics

Helpful advice for making the most of this Guide

  • •  Store intermediates in bulk containers and place them in a cool place away from direct lighting. Laboratory and storage room temperatures should be lower than 90 degrees F.
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Intermediates

Intermediates function as the starting point to help make most commercial and consumer products.
Intermediates are defined as chemicals that are combined with solvents to form other products. They provide the base for materials produced in a variety of industries, including textiles, agriculture, cleaning and health care. The most common include chemical intermediates for clothing and other textiles, pharmaceutical intermediates for prescription drugs and dye intermediates used as food additives or as detergents. There are ... Read more